He is a former member of the famous showbiz teen group, "Gwapings" alongside Jomari Yllana and Eric Fructuoso.
His breakout roles in the movies Pare Ko, Mangarap Ka and Matimbang Pa sa Dugo featured him as a lead star. In 1996, he received Best Actor and Best Supporting Actor nominations for the 3 aforementioned movies he did. However, the year 1998 started a downward spiral in Fernandez's career and personal life following an assault case that was filed against him by an American socialite and the break-up with his then-girlfriend Claudine Barretto. His home studio Regal Films attempted to launch him as an action star in the movies Sonny Segovia: Lumakad Ka Sa Apoy and Walang Katumbas Ang Dugo but both movies flopped at the box-office.
After a two-year hiatus from a drug rehabilitation which follows his acquittal in the assault case, Fernandez returned to the movie scene via Biyaheng Langit and Dos Ekis opposite sexy actresses Joyce Jimenez and Rica Peralejo, respectively. In 2003, he had disappeared once again from show business and underwent rehabilitation for drug dependence for the second time. In 2005, he was released from rehab and made his comeback in show business. After his release in rehab, he said in his words, "I hope the moviegoers will welcome me back. Now, I realize more than ever that I'm made for showbiz and I'll always be in showbiz."
Recently, he is one of GMA-7's leading actors with his critically-acclaimed performances on TV series such as Impostora (2007), Kamandag (2007), Ako si Kim Samsoon (2008), Luna Mystica (2008-09) and currently on All About Eve.
He is the son of the late actor Rudy Fernandez and actress Alma Moreno. He is also the half-brother to Vandolph Quizon and stepson of Lorna Tolentino.
In 1995, he had a past relationship with actress Claudine Barretto.
Mark has one daughter from his deceased girlfriend and has two sons from his current wife Melissa Garcia.
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